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Quantifying Lung Water Density with Ultrashort Echo Time Yarn-Ball MRI

  • Author / Creator
    Meadus, William Q
  • Pulmonary edema (PE) involves an excess of extravascular lung water (EVLW) due to an imbalance in fluid filtration which results in hypoxia and respiratory distress. Cardiogenic pulmonary edema is a primary clinical feature and therapeutic target in acute heart failure. Current methods in measuring EVLW are lacking, so this study aimed to provide quantitative imaging of water density in the lung parenchyma through MRI. This thesis illustrates a novel Yarn-Ball (YB) ultrashort TE (UTE) k-space trajectory along side an automated image processing approach. Efficiency optimized UTE-YB k-space trajectories were designed for breath-hold and free-breathing acquisitions. These provide full torso spatial coverage with minimal T1 and T2* weighting at 3T. A composite of all solid tissues surrounding the lungs (muscle, liver, heart, blood-pool) was used for the lung water density signal referencing and B1-inhomogeneity correction which results in relative water density based images. Automated region-growing based lung segmentation isolates relevant lung parenchyma voxels for final relative lung water density (rLWD) values. Acquisition-time matched 3D radial acquisitions were compared to YB. Sponge phantom experiments were used to validate absolute water density quantification. Phantom experiments showed excellent agreement between sponge wet weight and imaging-derived water density. Breath-hold (13 seconds) and free-breathing (∼2 minutes) YB acquisitions in volunteers (2.5 mm isotropic resolution) had negligible artifacts and good lung parenchyma SNR (>10:1). Whole lung average rLWD values were 28.6±3% (automated analysis) with good test/re-test reproducibility (ICC=0.87-0.99). Radial acquisitions with matched durations had significantly reduced fully sampled fields of view resulting in prominent undersampling artifacts. Quantitative lung water density imaging with an optimized YB acquisition is possible in breath-hold or short free-breathing studies and may prove invaluable in the measurement and tracking of PE.

  • Subjects / Keywords
  • Graduation date
    Spring 2020
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/r3-nkkx-4c58
  • License
    Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.