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Renal function and control during early altitude acclimatization

  • Author / Creator
    Steele, Andrew R
  • Renal acclimatization is an important aspect of high-altitude adaption coordinating diuresis, acid-base status, natriuresis, renal hemodynamics and kidney filtration. Renal blood flow, glomerular filtration rate, active renin, plasma aldosterone concentration, NT pro-brain natriuretic peptide (BNP), urine volume, urine microalbumin, HCO3-, PCO2, and PO2, were measured in twenty-four lowlanders (28 ± 7 years; 3 female) at 344 m and again at 4330 m following one (ATL1) and seven (ATL7) days of acclimatization. Renal blood flow decreased significantly from sea-level (931.4 ± 392.3 ml/min) to ATL1 (626.4 ± 364.8 ml/min; p<0.05) however rebound to sea-level values by ATL7 (892.8 ± 334.1 ml/min). Glomerular filtration rate was significantly decreased at ATL7 (86.4 ± 17.4 ml/min at ATL7) compared to sea-level (101.8 ± 21.1 ml/min; p<0.05). Plasma aldosterone concentration was the only hormone measured that reached significance (sea-level 121.7 ± 92.5 vs ATL7 182.7 ± 104.9 mmol/L; p<0.05). Lowlanders produced more urine at high-altitude (ATL1: 680.1 ml/9-hour and ALT7: 756.9 ml/9-hour) compared to sea-level (535.3 ± 277.8 ml/9-hour) reaching significance by ATL7 (p<0.05). Urine microalbumin was not significantly different at any time point. HCO3- was significantly decreased from sea-level (25.8 ± 1.7 mmol/L) and ATL1 (24.6 ± 1.9 mmol/L) compared to ALT7 (19.9 ± 2.0 mmol/L; p<0.05). PCO2 was significantly higher at sea-level (38.4 ± 3.2 mmHg; p<0.05) compared to ATL1 (33.1 ± 3.3) and ATL7 (28.2 ± 2.6 mmHg). PO2 was higher at sea-level (100.6 ± 18.4 mmHg; p<0.05) compared to ALT1 (41.5 ± 7.3 mmHg) and ATL7 (50.7 ± 3.9 mmHg) however increased during ATL7. Our findings suggest glomerular filtration rate decreases with continued high-altitude occupancy. Plasma aldosterone concentration decreases during prolonged hypoxia to cause diuresis. HCO3- excretion occurs to restore the acid-base status, which is evident by late acclimatization (ATL7).

  • Subjects / Keywords
  • Graduation date
    Spring 2020
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/r3-7enp-t394
  • License
    Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.