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Overcoming the Size Barriers in Pediatric Ventricular Assist Device Support

  • Author / Creator
    Conway, Jennifer
  • Mechanical circulatory support has become a therapeutic option for children with advanced heart failure. This type of support is often used to bridge patients to heart transplantation with approximately a third of all patients listed for transplant requiring some form of mechanical support. While there are a number of different devices to choose from the outcomes for the different devices may vary based on patient characteristics including size. Therefore a research program was established to address the following questions to help guide the management of pediatric patients with advanced heart failure: 1.What are the clinical characteristics of children <10Kg undergoing mechanical circulatory support (MCS) as a bridge to transplant? 2.How do infants <10Kg with cardiomyopathy (CM) vs. congenital heart disease (CHD) requiring MCS pre-transplant differ? 3.What are the outcomes for children <10Kg based on the first MCS device used as a bridge to transplant (ECMO vs.VAD)? 4.What are the clinical characteristics of pediatric patients receiving a Heartware HVAD System? 5.What are the outcomes of pediatric patients receiving a Heartware HVAD System? 6.Does the survival for children with a Heartware HVAD system differ based on body surface area (BSA ≤ 1m2 vs. >1m2)?

  • Subjects / Keywords
  • Graduation date
    Spring 2021
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/r3-7cem-en10
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.