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Development of Metal-Catalyzed Decarboxylative Cross-Coupling Reactions

  • Author / Creator
    Moon, Patrick J.
  • Carboxylic acids are a ubiquitous class of molecules in the field of organic chemistry and represent versatile building blocks in synthetic chemistry. Methods that enable the formation of new carbon–carbon or carbon–heteroatom bonds from carboxylic acids via the extrusion of carbon dioxide can present complementary reactivity and chemoselectivity to alternative cross-coupling reactions that use preformed organometallics reagents. While most carboxylic acids are typically considered stable, several strategies have been developed to promote decarboxylation and subsequent functionalization. This thesis describes the development of new methods for the decarboxylative functionalization of aliphatic carboxylic acids, using Cu, Ir, and Pd-catalysis.

  • Subjects / Keywords
  • Graduation date
    Fall 2019
  • Type of Item
    Thesis
  • Degree
    Doctor of Philosophy
  • DOI
    https://doi.org/10.7939/r3-r4ec-bh09
  • License
    Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.